ZIA CP000185 10317 (ZIA) | |||
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Title | Early Detection of Esophageal Cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Dawsey, Sanford | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $316,012 | Project Dates | 06/27/2005 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Digestive Diseases (100.0%) |
Esophagus (85.0%) Stomach (15.0%) |
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Research Type | |||
Chemoprevention Technology and/or Marker Testing in a Clinical Setting |
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Abstract | |||
The purpose of this study is to develop clinically useful techniques for early detection and treatment of esophageal cancer. The study has four parts: (1) primary screening studies, to develop accurate, cost-effective and patient-acceptable primary screening tests for esophageal precursor and early invasive lesions; (2) endoscopic localization studies, to endoscopically visualize foci of dysplasia and early cancer; (3) endoscopic therapy studies, to develop focal curative endoscopic therapies for high-grade dysplasias and early invasive cancers; and (4) chemoprevention studies, to evaluate the ability of oral chemopreventive agents to reduce progression or cause regression of low-grade esophageal dysplasias. Most of the study activities are carried out in Linxian, China, a county in north central China which has very high rates of esophageal cancer. |